PMIT: Preclinical Modeling

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Welcome to the Preclinical Modeling Facility, part of the Preclinical Modeling, Imaging & Testing Core (PMIT) at the Koch Institute. The Preclinical Modeling Facility and the Preclinical Imaging and Testing Facility work very closely together to accelerate translation of laboratory discoveries toward clinical implementation for patients. The PMIT Core combines expertise and instrumentation to:

  • facilitate the generation and high-resolution characterization of disease models
  • assist investigations of the mechanisms of disease development
  • enable the evaluations of drug efficacy and resistance
  • provide the means for testing novel strategies and devices for disease detection and drug delivery

The PMIT Core's mission is to streamline the path from the development of new therapeutic, diagnostic and basic discovery biomedical tools at the bench to their evaluation within a valid biological system.

The Preclinical Modeling Facility provides fee-for-service support to all MIT investigators who

  • utilize specialized in vitro cells such as stem cells, organoids, or primary cell lines 
  • generate or analyze novel mouse models to study human diseases such as cancer

We support whole mouse CRISPR-mediated gene editing and we have extensive experience with optimization of finicky cell cultures and are available to tackle any challenge with you.

We also provide a customizable set of service options to match the specific needs of each project, including consultative advice and troubleshooting, complete tissue culture and microinjection services within our dedicated facilities or hands-on training to enable investigators to perform these experiments either at their own laboratory or within our facilities.


Services are scheduled on a first-come, first-served basis after approval. Access is available to all members of the MIT community, to the extent permitted by available capacity. Priority access is given to KI members, NCI-funded research projects and other contributing user groups in recognition of funding support. In special circumstances, access may be available to non-MIT users (details available on request from the Scientific Director, Aurora Burds Connor).

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