The Integrated Genomics and Bioinformatics Core is comprised of the Genomics Facility and the Barbara K. Ostrom Bioinformatics Facility. Together, these shared institutional resources provide Koch Institute investigators with support throughout all phases of modern genomics experimentation.
The Barbara K. Ostrom (1978) Bioinformatics Facility is a shared institutional resource that enables KI investigators to leverage bioinformatics methods in their research projects. Core staff are experienced in transcriptomic (bulk, single-cell and spatial RNA-Seq), variant (SNP and CNV), regulatory (ChIP, ATAC, CUT&RUN, HiC) and custom analysis routines.
Services Include:
- Project-based collaboration between core staff and researchers.
- Classroom training sessions on a variety of computational, data science and bioinformatics topics.
- Custom training sessions on requested topics.
- Assistance with the usage of local research computing resources (facilitation).
- Bioinformatics software deployment using conda environments and docker containers.
- Data management support including submission of data to public repositories.
Access is available to all members of the MIT community, to the extent permitted by available capacity. In recognition of funding support, priority access is given to members of the Core’s sponsoring entities (Koch Institute, MIT Biology, MIT Biological Engineering and MIT Center for Environmental Health Science) and NCI-funded research projects. In special circumstances, access may be available to non-MIT users (details available on request from the Facility Scientific Director, Charlie Whittaker)
The Bioinformatics & Computing Core is supported in part by funding provided to the Koch Institute from a National Cancer Institute Cancer Center Support Grant.
