Assay development and screening

  • Small molecule or lentiviral screening, including combination experiments
  • Cell-based assays (e.g. cytotoxicity, qPCR prep, etc)
  • Biochemical assays
  • Alphascreen/AlphaLISA
  • High content/high throughput imaging in plate and slide format
  • General liquid handling (plating, compound delivery, serial dilutions, plate washing, etc.)
  • 96 or 384 well formats available for most screens
  • Both high throughput primary screens as well as lower throughput assays for follow-up studies
  • High throughput Western Blot detection

Additional Services

  • Mycoplasma testing (now available through the Preclinical Modeling Facility)
  • Cell line expansion, distribution and repository (MIT community only; now available through the Preclinical Modeling Facility)
  • High throughput Chromatin Immunoprecipitation (ChIP) prep (from tissue or cells)
  • Discounted consumables (plates, media, common reagents, tips) ~ not currently available
  • BL2+ resources, including shared workspace, training, equipment and consumables

Technical Expertise

  • Selection of assay and screening formats, assay development and optimization
  • Consulting services for researchers with specific automation or liquid handling needs
  • Tissue culture consultation
  • Engineering consultation