TPSI: Spatial Imaging

fluorescent microscopy image of nanoparticles in lung tissue

The Spatial Imaging Facility, part of the Tissue Processing & Spatial Imaging Core, provides experimental consultation, fee-for-service imaging assistance, and training in and access to several imaging platforms, image acquisition equipment, and data analysis software packages.

Services include:

  • consultation on fluorophores and experimental design
  • light and epifluorescence microscopy
  • fluorescent slide scanning
  • scanning confocal microscopy
  • multiphoton scanning confocal microscopy and intravital imaging
  • deconvolution-based microscopy for sensitive, high-resolution fluorescence imaging
  • 3D structured illumination microscopy
  • total internal reflection fluorescence (TIRF) microscopy
  • other advanced fluorescence microscopy techniques such as fluorescence recovery after bleaching (FRAP) and Förster resonance energy transfer (FRET)

Access is typically reserved for KI members.  Depending on available capacity, access may be available to non-MIT users (details available on request from Core Director Jeffrey Kuhn).

The Tissue Processing & Spatial Imaging Core is supported in part by funding provided to the Koch Institute from a National Cancer Institute Cancer Center Support Grant.

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